Neticonazole Hydrochloride( —— )

Catalog No. M19872 CAS No. 130773-02-3

Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Neticonazole Hydrochloride
Note

Research use only, not for human use.
Brief Description

Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.
Description

Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.
In Vitro

Western Blot Analysis Cell Line:C4-2B cells Concentration:10 μM Incubation Time:48 hours Result:Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.
In Vivo

Animal Model:Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cellsDosage:1 ng/kg, 10 ng/kg and 100 ng/kg Administration:Oral gavage; daily; for 15 days Result:Significantly improved the survival of IDB mice with CRC xenograft tumors.
Synonyms

——
Pathway

Microbiology/Virology
Target

Antifungal
Recptor

Antifungal
Research Area

Cancer
Indication

PCa(prostatic Cancer)

Chemical Information

CAS Number

130773-02-3
Formula Weight

338.9
Molecular Formula

C17H22N2OS.HCl
Purity

>98% (HPLC)
Solubility

DMSO: 50 mg/mL
SMILES

Cl.CCCCCOc1ccccc1\C(=C/SC)n1ccnc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Datta A et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.

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